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Oral Antiviral Therapy Options for HBV Currently, a total of six oral antiviral medications have been approved by the FDA for the treatment of chronic HBV, including three nucleoside analogues (entecavir, lamivudine, and telbivudine) and three nucleotide analogues (adefovir, tenofovir alafenamide, and tenofovir DF) (Table 1).[4] Among these, tenofovir alafenamide, tenofovir DF, and entecavir are considered first-line therapy